This Question is very vague. There could be many reasons for for an application to get slower. Slow network connection, poorly written applciation code, not keeping the right balance between number of roundtrips and task, poorly written SQL code, Slow or not enough Hard disks, Not enough memory, Not enough, slwo CPU, Poorly configured Server Settings, and many more. This site carried out a series of articles a few years ago. (I can't remember the title, but something connected to "Checklist"
You can use profiler and PerfMon to capture whwts is happening on the server and identify the possible component. Based on your identification of the cause, you need to fix it.
Just a request: When you post a question on new topic, please try to start a new thread. It is easy for many perople to see and answer and also easy for people who are searching for similar post to find quick answer. This thread talks about log shipping, Blocking and slow application, but is recorded as Log Shipping in the thread.