How to improve query performance

Hi,

Iam trying to execute one query. where query inclued many tables (which has primary key and foreign key's). Its taking 5 min 38 sec's long time to execute...

I found the missing indexes by using dmv query. what I have to do next... to improve the performance of query
Iam giving details abt tables, keys, indexes and exicuting query also..



gimme suggetions to improve performance of above query..

thankx